https://www.selleckchem.com/pr....oducts/clozapine-n-o
The seizure duration was significantly lower in the groups of melatonin, thiamine, and thiamine and melatonin combination compared to the seizure control group. The latency times in these groups were significantly greater than the seizure control group. Moreover, MDA concentrations were lower in these groups compared to the seizure control group. Thiamine, melatonin and their combination can decrease the duration time of seizure and increase the latency period, which may result from inhibition of oxidative stress in the brain.