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This study will provide evidence for the exploration of the relationship between Agn2 and the prognosis of osteosarcoma and its mechanism. The private information from individuals will not be published. This systematic review also should not damage participants' rights. Ethical approval is not available. The results will be published in a peer-reviewed journal or disseminated in relevant conferences. DOI 10.17605/OSF.IO/GWQ53. DOI 10.17605/OSF.IO/GWQ53. As an anticancer gene, microRNA-145 (miRNA-145) inhibits the growth, migration, and