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miR-34a and SIRT1 levels were associated with MDD symptoms especially in early-life stressed patients. Small sample size, no information on personality comorbidity and suicidal history, cross-sectional definition of remission, and lack of follow-up. Our findings suggest that the levels of global DNA methylation, TOLLIP, and VEGF-a reflect pathophysiological changes associated with MDD that are independent from the long-term effects of low parental care. This study also suggests that SIRT1 may be an additional variable distinguishing the
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