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The coexistence of these two disorders provides evidence of SLC2A9 variant could act as a modifier change, with synergistic actions, that could promote cystogenesis and rapid ADPKD progression. This is the first case of coexistence of PKD1 and SLC2A9 mutations treated with tolvaptan. © 2020 John Wiley Sons A/S. Published by John Wiley Sons Ltd.INTRODUCTION The objective of this study was to report on the clinical performance of non-invasive prenatal testing（NIPT）for trisomies 21, 18 and 13 in twin pregnancies and to defin