https://www.selleckchem.com/pr....oducts/GDC-0980-RG74
Potential therapeutic strategies for patients whose tumors harbor CYLD alterations are also discussed. IMPLICATIONS Alterations in CYLD gene are associated with HPV-associated cancers, contribute to NF-κB activation, and are implicated in invasion and metastasis. Dabrafenib, an inhibitor of mutated , has significant clinical activity in melanoma patients but is linked to a spectrum of cutaneous toxicities. Thus, our meta-analysis was conducted to evaluate the type, incidence and risks of dermatological toxicities from dabrafenib