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In an intravital microscopy tour de force reported in this matter of Immunity, Chauveau et al. show that T cells perform unidirectional, perivascular migration through the enigmatic limited area bridging networks.Positron emission tomography (PET) has proven to be an excellent device within the staging and handling of illness in oncology; however, [18F]fluorodeoxyglucose ([18F]FDG) continues to be the most widely used animal radiopharmaceutical despite large eco