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Migration of PMCs had been determined using Transwell assay. The expression of Shh, Gli1 and EMT markers including α-SMA, fibronectin, collagen we, snail1 and E-cadherin had been analyzed by RT-qPCR, western blot analysis, and immunofluorescence correspondingly. High sugar induction ended up being identified to market cellular migration while increasing the expression of Shh and Gli1 in a dose- and time-dependent manner in rat PMCs. Cyclopamine (CPN) was