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This study aimed to investigate the long-term effects of early stress by Tangshan earthquake on symptoms of depression in adulthood. A total of 1534 volunteers born and raised in Tangshan were investigated; finally, 1328 subjects were enrolled in the study. They were divided into three groups according to their birth dates infant exposure, prenatal exposure, and non-exposure. The questionnaires and psychological evaluation of all subjects were completed using a one-on-one psychological test. The rate of depressive symptoms in the prenatal