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In contrast, the ACF group was characterized by reduced ESPVR, decreased E , and enhanced meridional end-diastolic wall stress. VAC increased in both HF groups. Furthermore, LS was also impaired in both HF models (-5.9±0.6% vs -12.9±0.5%, TAC vs Sham [P.001], and -11.7±0.7% vs -13.5±0.4%, ACF vs Sham [P=.048]). Statistical analysis revealed that strain parameters were determined predominantly by afterload in the TAC group and by contractility in the ACF group, while preload had a minor effect. In the entire study population, LS show
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