https://www.selleckchem.com/pr....oducts/5-n-ethylcarb
CdA 0.1-1 µM significantly reduced granularity, phagocytotic ability and random migration of activated microglia. CdA 10 µM increased the IL-4-induced gene expression of Arg1 and LPS-induced expression of IL-1beta, TNF, iNOS, and Arg1, but protein secretion remained unaffected. CdA 10 µM potentiated the increased expression of anti-inflammatory TNFR2 but not TNFR1 induced by LPS. Conclusion Microglia acquire a less activated phenotype when treated with 0.1-1 µM CdA that putatively overlaps human CSF concentrations.
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