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This effect is explained in terms of destructive QI (DQI) for the meta-connected pyrrole and shifted DQI for the para-connected isomer. These results demonstrate modulation of antiresonances by molecular design and verify the validity of ECARs as a simple "pen-and-paper" method for predicting QI behavior. The principles offer new fundamental insights into structure-property relationships in molecular junctions and can now be exploited in a range of different heterocycles for molecular electronic applications, such as switches based on e