https://www.selleckchem.com/pr....oducts/exarafenib.ht
BACKGROUND Osteoclast activation is a hallmark of breast cancer-induced bone disease while little is known about the role of osteoblasts in this process. Recently, we identified the homeodomain protein TG-interacting factor-1 (Tgif1) as a crucial regulator of osteoblast function. In this study, we demonstrate that lack of Tgif1 also restricts the progression of breast cancer bone metastases. METHODS Transwell migration assays were used to investigate the osteoblast-breast cancer cell interaction in vitro. Molecular analyses included
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