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In such patients, TFR would be considered as a salvage therapy that could preserve the patient's anatomical integrity and ambulation. To the best of our knowledge, this is the first case of TFR for treatment of chronic persistent osteomyelitis in Vietnam. While TFR are still mainly indicated for oncology patients, TFR is anticipated to be performed more frequently for non-oncological disorders where there are extensive femoral bone loss and risk of amputation. To the best of our knowledge, this is the first case of TFR for treatment of