https://www.selleckchem.com/pr....oducts/CHR-2797(Tose
Although β-hairpins are widespread in proteins, there is still no universal tool to coax any small peptide to adopt a β-hairpin conformation, regardless of sequence. Here, we report that δ-linked γ( R )-methyl-ornithine ( δ MeOrn) provides an improved β-turn template for inducing a β-hairpin conformation in peptides. We have developed a synthesis of protected δ MeOrn as a building block suitable for use in Fmoc-based solid-phase peptide synthesis. The synthesis begins with l -leucine and affords gram quantities of the N α -
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