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25 exhibited a considerable increased risk of death compared with patients with LG-NF and DI≥0.25 (adjusted hazard ratio, 2.41 [95% CI, 1.61-3.62]; P less then 0.001), LG-NF and DI less then 0.25 (adjusted hazard ratio, 1.84 [95% CI, 1.24-2.73]; P=0.003), and LG-LF and D≥0.25 (adjusted hazard ratio, 2.27 [95% CI, 1.42-3.63]; P less then 0.001). In contrast, patients with LG-LF and DI≥0.25, LG-NF and DI less then 0.25, and LG-NF and DI≥0.25 had similar outcome. DI less then 0.25 showed incremental prognostic value in patients with LG-LF