https://www.selleckchem.com/pr....oducts/etomoxir-na-s
The systemic use of GABAB orthosteric agonist baclofen might be limited due to its detrimental properties sedation and motor impairment. In contrast, GABAB positive allosteric modulators produce less adverse effects. Using BHF-177 as a starting point, we found a new active scaffold the 6-aryl-quinazoline scaffold. Further elaborating the scaffold, we identified several in vitro and in vivo active compounds.POGZ is a pogo transposable element derived protein with multiple zinc finger domains. Many de novo loss-of-function (LoF)
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