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Seafarers are a special population. The issue of sexually transmitted diseases among seafarers is as old as navigation itself, and is a public health issue and a matter of concern for seafarers themselves. The purpose of this article is to review the literature on sexually transmitted infections (STIs) in professional seafarers in the 21st century, with a view to guiding maritime physicians in their practice. This is a Medline® and Scopus® literature review covering publications between 01/01/2000 and 31/12/2019. Out o