https://www.selleckchem.com/pr....oducts/abc294640.htm
As treatment for postsurgical pain (PSP) remains a major unmet medical need, the emergence of safe and innovative non-opioid drugs has been strongly coveted. Tetrahydrobiopterin (BH4) is an interesting molecule for gaining a better understanding the pathological mechanism of neuropathic pain. However, whether BH4 and its pathway are involved in the pathogenesis of PSP remains unclear. In this study, we found that early in a rat paw incision model, the gene expression of GTP cyclohydrolase 1 (GTPCH) and sepiapterin reductase (SPR), BH4