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ymphocyteratio (NLR), Platelet-to-lymphocyte ratio (PLR), Predictive score. To compare clinical outcome in patients of chronic myeloid leukemia (CML) with and without megakaryocytic clustering. Cross-sectional comparative study. Pathology Department and CML Clinic Oncology Department, King Edward Medical University from March 2018 to March 2019. Methodology Ninety-four patients diagnosed with chronic phase of CML were included. Complete record of complete blood count, splenomegaly, findings of bone marrow aspirate and trephine biopsy was