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The aim of this study was to assess the potential role of thyroglobulin (Tg) kinetics in predicting 2-[ F]-FDG-PET/CT results and overall survival (OS) in patients affected by differentiated thyroid carcinoma (DTC) and suspected recurrence. On hundred and thirty-nine patients were retrospectively included. All patients underwent 2-[ F]-FDG-PET/CT due to detectable Tg levels and negative [ I] whole-body scan. The last two consecutive serum Tg measurements before PET/CT were used for Tg-doubling time (TgDT) and Tg-velocity (Tg-vel) calcula