https://www.selleckchem.com/products/VX-809.html
CBP/P300 inhibition promoted the regeneration of intestinal organoids invitro and of crypts invivo. Remarkably, the administration of CBP/P300 inhibitors to mice 24 hours after lethal irradiation promoted Lgr5 intestinal stem cell and crypt recovery, resulting in improved mouse survival. Moreover, our data show that CBP/P300 inhibitors rescued irradiated mice from RIGS by delaying intestinal epithelial cell cycle progression after radiation. These data demonstrate that CBP/P300 inhibitors are effective medical countermeasures to mitigate