https://nsc27223inhibitor.com/....the-actual-affect-in
Here, we identified TMEM63B as an osmosensitive NSCC activated by hypotonic stress. TMEM63B is enriched when you look at the inner ear physical hair cells. Hereditary deletion of TMEM63B results in necroptosis of outer hair cells (OHCs) and modern hearing reduction. Mechanistically, the TMEM63B channel mediates hypo-osmolarity-induced Ca2+ influx, which activates Ca2+-dependent K+ networks required for the maintenance of OHC morphology. These conclusions demonstrate that TMEM63B is an osmosenso
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