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Here we utilized knockout mouse models and time-lapse microscopy to elucidate Gα and Gβ subunits contributing to complement C5a receptor-mediated chemotaxis. Complement C5a-mediated chemokinesis and chemotaxis were very nearly totally abolished in macrophages lacking Gnai2 (encoding Gαi2), consistent with a diminished leukocyte recruitment previously noticed in Gnai2-/- mice, whereas cells lacking Gnai3 (
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