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004). Carriers of FGB rs1800790 A allele and F13 rs5985T allele had lower K , prolonged CLT and higher ETP compared with major homozygotes (all p.05). After adjustment for fibrinogen, all differences remained significant (all p.01). There were no associations between the FGA rs6050 polymorphism and K , CLT or ETP. Our study showed that FGB rs1800790 and F13 rs5985 polymorphisms contribute to the prothrombotic fibrin clot phenotype and these effects are strong enough to be observed in the acute phase of PE. Our study showed that