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0ng/mL for CEA and  37.0 U/mL for CA19-9) was less significant than that based on the optimal cutoff values. Both elevated CEA and CA19-9 had no value dependency on RFS RFS curves were similar between extremely elevated CEA (≥ 54.0ng/ml) and intermediate CEA (5.4-54.0ng/ml) and between extremely elevated CA19-9 (≥ 224.0 U/ml) and intermediate CA19-9 (22.4-224.0 U/ml). The optimal cutoff values of preoperative CEA and CA19-9 for RFS were 5.4ng/ml and 22.4 U/mL, respectively, in patients with stages II and III colon cancer. Further re