https://www.selleckchem.com/pr....oducts/sanguinarine-
Despite the importance of Wnt signaling for adult intestinal stem cell homeostasis and colorectal cancer, relatively little is known about its role in colon formation during embryogenesis. The development of the colon starts with the formation and extension of the hindgut. We show that Wnt3a is expressed in the caudal embryo in a dorsal-ventral (DV) gradient across all three germ layers including the hindgut. Taking genetic and lineage tracing approaches, we describe novel dorsal and ventral hindgut domains and show that v