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lterations in our cohort were missense mutations associated with differentiated predominant histological subtypes and immunohistochemical SMARCA4/BRG1 and TTF-1 positive status.This article is devoted to a review of studies on the determination of trace elements in germanium and germanium dioxide. For this purpose, methods both with and without preliminary matrix separation procedure have been developed and applied. The advantage of methods without a matrix separation procedure is simple and fast sample preparation, since it does not r