https://www.selleckchem.com/pr....oducts/Glycyrrhizic-
Data showed that AST significantly upregulated the expression of NRF-2 gene (P less then 0.001) and protein (P less then 0.005) and also significantly decreased the production of BU-induced ROS (P less then 0.001). AST activated the NRF-2/HO-1 pathway that could remarkably restrain BU-induced apoptosis in SSCs. Interestingly, AST upregulated the expression level of apoptosis genes in the K562 cell line. The results of this study indicated that AST reduces the side effects of BU on SSCs without interference with its chemotherap