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Shock is a state in which the cardiovascular system fails to adequately deliver required substrates to maintain end-organ perfusion, tissue homeostasis, and cellular metabolism. Rapid recognition of shock and intervention is of utmost importance to reverse the shock state. This article reviews uncommon etiologies of shock classified in the following categories distributive, hypovolemic, cardiogenic, and dissociative shock.The focus of this narrative review is the differential diagnosis of disease involving the peripheral or lower motor neuron compo