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The report ends with special focus on future recommendations for the development of sustainable waste management strategies in order to control pollution due to plastics waste. This article is protected by copyright. All rights reserved.Heavily transfused patients frequently develop human leukocyte antigen (HLA) allo-immunization resulting in platelet transfusion refractoriness and a high risk for life-threatening thrombocytopenia. Data suggest complement activation leading to the destruction of platelets bound by HLA allo-antibod