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technique. PET radiomics features of the primary tumor seem promising for predicting the presence of nodal metastases not detected by visual analysis. © IGCS and ESGO 2020. No commercial re-use. See rights and permissions. Published by BMJ.Efforts to reduce surgical morbidity related to en bloc lymph node removal associated with cancer surgery led to the development of targeted lymph node sampling to identify the lymph node(s) most likely to harbor a metastasis. Through identification of one or only a few lymph nodes at highest risk,