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This method can measure DNA damage with a detection limit as low as 1.1 × 10-16 M, and it can distinguish DNA damage at low abundance down to 1.3 × 10-4%. Importantly, it can provide information about the occurrence of DNA damage in a specific gene and ascertain the DNA damage level in different cancer cell lines, offering a new approach for studying the physiological function of various DNA damages in human diseases.In this study, a novel method for the direct coupling of metal probe microextraction (MPME) and a dielectric barrier dis
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