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All patients developed hypogammaglobulinemia with a median onset time of 2weeks post-infusion. IgG recovered in 6 patients with a median time on day 184(89-346). IgM recovered on days 212, 242, and 346 in 3 patients. IgA recovered most slowly and remained low 1year postinfusion. A total of 9 infections occurred in 6(28.57%) patients. Our data showed prolonged reconstitution of immune function, especially humoral immunity, in R/R B cell ALL patients receiving anti-CD19 CAR-T cell therapy. Our data showed prolonged reconstitution of i