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Expected final online publication date for the Annual Review of Genetics, Volume 55 is November 2021. Please see http//www.annualreviews.org/page/journal/pubdates for revised estimates.Perfectly orchestrated periodic gene expression during cell cycle progression is essential for maintaining genome integrity and ensuring that cell proliferation can be stopped by environmental signals. Genetic and proteomic studies during the past two decades revealed remarkable evolutionary conservation of the key mechanisms that control cell cycle-regul
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