https://www.selleckchem.com/pr....oducts/bgb-283-bgb28
Compared to adjacent normal tissue, PRMT1 was highly expressed in the CRC zone in clinical specimens, which was correlated with poor overall survival in patients with locally advanced CRC. These results demonstrate that PRMT1-mediated methylation of NONO at R251 promotes CRC growth and metastasis, and suggest that PRMT1 inhibition may be an effective therapeutic strategy for CRC treatment regardless of KRAS mutation status.Current evidence indicates that resistance to the tyrosine kinase-type cell surface receptor (HER2)-targeted
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