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In addition, treatment of donor cells with the RNA polymerase I (Pol I) inhibitor cx5461 caused similar effects on SCNT embryos. These results indicated that transient inhibition of rDNA transcription in donor cells facilitated the establishment of functional nucleoli and improved preimplantation development of SCNT embryos. © 2020 Federation of American Societies for Experimental Biology.BACKGROUND The active ingredients in sunscreen products are ultraviolet (UV) filters, many of which are known potential all