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Sixty-seven percent of complications occurred with use of the 2.4 mm cryoprobe ( = 0.036). Concordance between the histologic diagnosis and final clinical diagnosis was observed in 62.5% of patients and the pathology guided the final treatment in 71% ( = 0.027) with Kappa-concordance of 0.60 ( 0.001). Cryobiopsy is becoming part of the diagnostic evaluation in patients with indeterminate DPLD or hypoxemic respiratory failure. TBLC is easy to perform and has a favorable safety profile. Thoracic specialists should consider adding TBL