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Macrophages had been isolated from the villous core of term, person placentae delivered through nonlaboring, elective Cesarean sections and exposed to combinations of increased glucose (30 mM), insulin (10 nM) plus the saturated lipid palmitic acid (palmitate, 0.4 mM). RESULTS We unearthed that palmitate alone induced the activation associated with the nucleotide-binding oligomerization domain-like receptor (NLR) Family Pyrin Domain Containing 3 (NLRP3) inflammasome in placental macrophages, th