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espectively, for diffusion-T2). Conversely, none of the conventional quantitative MRI parameters were able to differentiate lesions and normal-appearing white matter. Lastly, we found that the abnormal T1-T2, diffusion-T1, and diffusion-T2 components and their axonal damage images were strongly correlated with quantitative APP staining (r = 0.876, P  less then  0.001; r = 0.727, P  less then  0.001; and r = 0.743, P  less then  0.001, respectively), while producing negligible intensities in grey matter and in normal-appearing white matte