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Additionally, we found that the manner combination of the flanking consonants, fricative-fricative versus fricative-stop, also has an effect, at least for some speakers; however, unlike the effect of C1 place, the direction of the manner combination effect varies across speakers with some deleting more often in fricative-stop environments and others more often in fricative-fricative environments. In-house developed liquid-chromatography mass spectrometry (LC-MS/MS) methods are used more and more frequently for the simultaneous quantifica
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