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vanced delivery systems. H2S-induced S-sulfhydration on proteins are potential novel targets for therapeutic intervention and drug design for the skin, which may lead to the development and application of H2S-related drugs for dermatological diseases.Introduction Hydrogen sulphide (H2S) is one of the gasotransmitters that was reported to have a cardioprotective effect at its physiological levels in blood. Previous determinations of H2S levels in cardiovascular disease (CVD) patients suffered from diversity of analytical methods, diffe