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21, 95% CI 0.05-0.96, = 0.044). In both age-groups, lower baseline clamp-derived β-cell responses predicted month 12 and month 21 glycemic worsening ( 0.01). Lower baseline OGTT-derived β-cell responses predicted month 21 worsening ( 0.05). In youth, higher baseline HbA and 2-h glucose predicted month 12 and month 21 glycemic worsening, and higher fasting glucose predicted month 21 worsening ( 0.05). In adults, lower clamp- and OGTT-derived insulin sensitivity predicted month 12 and month 21 worsening ( 0.05). Glycemi

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