https://www.selleckchem.com/pr....oducts/AZD2281(Olapa
Finally, the effect of FAP-tPDT on arthritis development was determined in mice with collagen-induced arthritis. 28H1-700DX was able to efficiently induce FAP-specific cell death in vitro. Accumulation of the anti-FAP antibody in arthritic knee joints was not affected by conjugation with the photosensitizer. Arthritis development was moderately delayed in mice with collagen-induced arthritis after FAP-tPDT. Here we demonstrate the feasibility of tPDT to selectively target and kill FAP-positive fibroblasts in vitro and modulate
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