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This technique was linear when you look at the variety of 5.00-3000 ng/mL for anaprazole and 1.00-600 ng/mL when it comes to four metabolites. The reduced limitation of quantitation ended up being established at 5.00 ng/mL for anaprazole and 1.00 ng/mL when it comes to metabolites. The quantitative method was made use of to guage the pharmacokinetics of anaprazole in phase I clinical trials. BACKGROUND Fluoroquinolones and rifampicin tend to be antibiotics frequently employed to treat osteoarticular