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How a VC Can Affect Your Heart PVCs are commonplace and can be experienced by a wide range of people without causing any problems. If they happen frequently, PVCs may weaken your heart and increase your risk of heart failure. The heart's rhythm is controlled by a bundle of fibers located in the upper right part of your heart. This is known as the sinoatrial node or SA. Electrical signals travel to the ventricles, or lower chambers of the heart. Causes PVCs occur when the electrical impulse that usually begins your hea