https://www.selleckchem.com/pr....oducts/mcc950-sodium
learance or immune toxicities that have been reported for IgG1 antibodies. In conclusion, we have shown that VISTA-induced immune suppression can be reversed by blockade of the functional C-C' loop region of VISTA with a first-in-class rationally targeted and non-depleting IgG4 isotype anti-VISTA antibody, HMBD-002. This antibody represents a highly promising novel therapy in the VISTA-suppressed ICT non-responder population. In conclusion, we have shown that VISTA-induced immune suppression can be reversed by blockade of the
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