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05). Among all patients, IGF-1 and GH levels showed a positive correlation with the LGV (p0.001; r=0.52; r=0.6, respectively). However, Schirmer, TBUT, and OSDI scores did not show any difference among the three groups at each visit (p0.05). Acromegaly patients may have larger lacrimal glands compared to the controls and this increase correlated with the increased IGF-1 and GH levels. Lacrimal gland volume may have no effect on its tear film related functions. Acromegaly patients may have larger lacrimal glands compared to the c