https://www.selleckchem.com/pr....oducts/Rapamycin.htm
We report herein the facile synthesis of indole-fused six-, seven-, or eight-membered N,O-heterocycles through rhodium-catalyzed C-H acetoxylation/hydrolysis/annulation. The notable features of this method include C-H acetoxylation using NH-indole as the intrinsic directing group, high functional group compatibility, and construction of indole-fused medium-sized rings.Ion-specific effects on the solubility of nonpolar solutes and on the solute-solute hydrophobic interaction in aqueous electrolyte solutions are studied on the basis of
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