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81 ± 0.42 and 1.72 ± 0.33, respectively (P less then 0.001). Univariate analysis showed that the ICA TI were positively correlated with each SVD MRI marker (P less then 0.001), and the correlation coefficients (r s ) were 0.57, 0.42, 0.30, and 0.26 for EPVSs, WMHs, CMBs, and lacunes, respectively. The adjusted ORs of the ICA TI were 1.52 (95% CI 1.44-1.60, P less then 0.001) for EPVS grade 1, 2.05 (95% CI 1.93-2.18, P less then 0.001) for EPVS grades 2-4, and 1.09 (95% CI 1.03-1.15, P = 0.004) for WMH grade 3. Conclusions The TI

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