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How a VC Can Affect Your Heart Many people have occasional PVCs and have no issues. If they happen frequently, PVCs may weaken your heart and increase the risk of heart failure. A bundle of fibers located in the top right portion of your heart (the sinoatrial node, also known as SA) typically regulates your heart's rhythm. Electrical signals travel from this node to the lower chambers of your heart, or ventricles. Causes PVCs happen when the electrical impulse that normally begins your heartbeat at a point called the sinus
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